Face PAH with
all you’ve got
 
Dosing for UPTRAVI® (selexipag) is not one-size-fits-all1
Each patient has a personal dose based on how his or her body responds and adjusts to the medicine. If you experience side effects that you cannot tolerate, your doctor may lower your dose in order to find what’s right for you.
Getting started with UPTRAVI
Don’t miss the call from your specialty pharmacy.
Your healthcare provider orders UPTRAVI from a specialty pharmacy. They will also determine if you need additional support services from a nurse to get started.
After your doctor prescribes UPTRAVI, they will review important information about UPTRAVI with you. They can also help you enroll in Actelion Pathways®, a patient support program.
You don’t have to go through the process alone. If you enroll in Actelion Pathways, an Actelion Pathways Case Manager will coordinate with your healthcare provider, specialty pharmacy, and insurance company to check if you have coverage for UPTRAVI and inform you of potential financial assistance programs based on your eligibility.
Before your prescription is filled, you’ll get a call from a specialty pharmacy to discuss coverage and shipping information. If you miss or accidentally decline the call, please call back as soon as possible so your medication is not delayed.
If your doctor has arranged any additional services, the specialty pharmacy will schedule those as well.
Once everything is all set, the pharmacy will ship the prescription directly to your door.
Discovering Your Dose
The Dose Adjustment Phase (also called titration) is how you and your doctor find your personal dose.
This is just a temporary part of treatment until you reach the dose that is right for you.
-How the Adjustment Phase works
Your doctor will start you at the lowest dose of UPTRAVI: One 200 microgram (mcg) tablet, twice a day—once in the morning and once in the evening.
Starting with the lowest dose, your doctor will slowly increase your dose based on how you adjust to treatment until you reach your personal dose.
At some point during the Dose Adjustment Phase, you may experience side effects. If you experience side effects that you cannot tolerate, your doctor may lower your dose in order to find your personal dose.
UPTRAVI dose strengths range from 200 mcg to 1600 mcg.
DO NOT CHANGE YOUR DOSE OR STOP taking UPTRAVI unless your doctor tells you to.
+Which tablets will I take during dose adjustment?
Depending on which dose your doctor tells you to take, you may use a combination of tablets. With each dose adjustment during this phase, your doctor can easily add or remove a single tablet to increase or decrease your dose as needed.
For example:
If your dose is at 600 mcg twice a day, you’ll take three 200 mcg tablets in the morning and three 200 mcg tablets in the evening
If you reach a dose of 1000 mcg or higher, you may begin using 800 mcg tablets—along with 200 mcg tablets—until you reach your personal dose
The goal is not to get to the highest dose of UPTRAVI, it’s to get to the dose that’s right for you
+What happens after the Dose Adjustment Phase?
After the Dose Adjustment Phase, you may have found your personal dose of UPTRAVI. Your doctor may call this your maintenance dose. You’ll then take a single tablet of your personal (maintenance) dose twice a day, unless your doctor tells you otherwise.
+What should I do if I miss a dose?
If you miss a dose of UPTRAVI, take it as soon as you remember. If your next scheduled dose is due within 6 hours, skip the missed dose. Take the next dose at your regular time.
If you miss 3 or more days of UPTRAVI, call your doctor to see if your dose needs to be changed.
If you take too much UPTRAVI, call your healthcare team or go to the nearest hospital emergency room right away.
+The Importance of Staying Involved in Your Therapy
Managing PAH can take some time and patience. Being open and honest with your healthcare team can be good for you.
Stick with the plan that you and your healthcare team decide is best for you
Remember to stay hopeful and focused on the big picture of how UPTRAVI can help you
Tell your doctor about any side effects you have while taking UPTRAVI
The goal is not to get to the highest dose of UPTRAVI, it’s to get to the dose that’s right for you
Don’t be discouraged if you have to reduce your dose or stay on a lower one
In the clinical study, there were similar results when people reached the dose of UPTRAVI that was right for them
+Who to Talk to for Support
Knowing what to expect beforehand can help you and your caregiver or loved ones be prepared for treatment
Ask your PAH healthcare team about ways to help manage some common side effects when you start UPTRAVI
When you were prescribed UPTRAVI, your doctor may have requested additional services to help you during the Dose Adjustment Phase (titration)
How to
take UPTRAVI1
Take UPTRAVI exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI twice a day. Taking UPTRAVI with food may help you tolerate UPTRAVI better.
Swallow UPTRAVI tablets whole. Do not split, crush, or chew tablets.
Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI.
In a clinical trial of UPTRAVI, the most common side effects included1
UPTRAVI
n=575
Those not taking UPTRAVI n=577 Those not taking UPTRAVI n=577
Headache 65% 32%
Diarrhea 42% 18%
Jaw pain 26% 6%
Nausea 33% 18%
Muscle pain 16% 6%
Vomiting 18% 9%
Pain in arms
or legs
17% 8%
Temporary reddening of the skin (flushing) Temporary
reddening
of the skin
(flushing)
12% 5%
Joint pain 11% 8%
Low red blood cell count 8% 5%
Less appetite than usual 6% 3%
Rash 11% 8%
What you can do to help manage side effects:
Taking UPTRAVI with food may help you tolerate the dose better if you’re having side effects with UPTRAVI.
Tell your family and friends that you are starting UPTRAVI and may need their assistance and support.
Always tell your doctor about any side effects, and do not change doses on your own. If you experience side effects that you cannot tolerate, your doctor may lower your dose in order to find your personal dose.
DO NOT CHANGE YOUR DOSE OR STOP taking UPTRAVI unless your doctor tells you to.
If you’re a caregiver for someone with PAH, think of yourself as part of their support team
Caregivers can play several key roles
Educate
Learn about resources available to those with PAH. Click here for associations related to PAH.
Partner
Be a partner for the person you’re caring for throughout treatment, joining doctor’s appointments, asking questions, and taking notes.
Monitor
Keep track of your loved one’s progress and report to the doctor. Remain aware of dose adjustments and help your loved one track their side effects.
Advocate
Make your voice heard when working with the healthcare team to ensure all of your questions are answered and all of your loved one’s needs are met.
What caregivers can do about side effects
As a caregiver, you can help the person you’re caring for keep track of side effects. Be aware of and alert to the most common side effects. Keep track of their side effects at each dosage level. Speak up for them with their doctor about the impact of side effects. Encourage them to take UPTRAVI with food to potentially tolerate their dose better.
Whether you are a patient or a caregiver, there’s more you can learn
There are resources to help you learn more about and get started on UPTRAVI.
IMPORTANT SAFETY INFORMATION
EXPAND +
What is the most important information about UPTRAVI?
Who should not take UPTRAVI?
  • Do not take UPTRAVI if you take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

What should I tell my doctor before taking UPTRAVI?

Tell your doctor if you:

  • Have liver problems
  • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
  • Are pregnant or plan to become pregnant. It is not known if UPTRAVI will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI passes into your breast milk. You and your doctor should decide if you will take UPTRAVI or breastfeed. You should not do both
  • Have any other medical conditions
  • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements
What are the possible side effects of UPTRAVI?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Keep UPTRAVI and all other medicines away from children.

What other medicines might interact with UPTRAVI?
  • UPTRAVI and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor
How should I take UPTRAVI?
  • Take UPTRAVI exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI twice a day. Taking UPTRAVI with food may help you tolerate UPTRAVI better
  • Swallow UPTRAVI tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI
  • UPTRAVI is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

+
IMPORTANT SAFETY INFORMATION
What is the most important information about UPTRAVI?
+
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension

IMPORTANT SAFETY INFORMATION
What is the most important information about UPTRAVI?
Who should not take UPTRAVI?
  • Do not take UPTRAVI if you take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

What should I tell my doctor before taking UPTRAVI?

Tell your doctor if you:

  • Have liver problems
  • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
  • Are pregnant or plan to become pregnant. It is not known if UPTRAVI will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI passes into your breast milk. You and your doctor should decide if you will take UPTRAVI or breastfeed. You should not do both
  • Have any other medical conditions
  • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements
What are the possible side effects of UPTRAVI?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Keep UPTRAVI and all other medicines away from children.

What other medicines might interact with UPTRAVI?
  • UPTRAVI and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor
How should I take UPTRAVI?
  • Take UPTRAVI exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI twice a day. Taking UPTRAVI with food may help you tolerate UPTRAVI better
  • Swallow UPTRAVI tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI
  • UPTRAVI is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

References: 1. UPTRAVI® (selexipag) full Prescribing Information. Actelion Pharmaceuticals US, Inc.