Delaying PAH progression
starts with you
Delaying PAH
progression
starts with you
 
PAH stops at nothing
Are you armed with information you need to ask your doctor about delaying PAH progression?
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Considering every pathway is key
Arteries in the lungs may be affected when there is either too much or too little of the three naturally occurring substances in your body, but there are medications available that can target each of these three key pathways.1
Nitric Oxide Pathway
Phosphodiesterase type-5 inhibitors (PDE-5 inhibitors) work here.1
Endothelin Pathway
Endothelin receptor antagonists (ERAs) work here.1
Prostacyclin Pathway
Prostacyclin, prostacyclin analogs, and prostacyclin receptor agonists work here.1
Prostacyclin activates a process that helps open arteries.1,2 UPTRAVI® (selexipag) works in a similar way to help open the arteries.3
UPTRAVI can help when used alone or in combination with other PAH medications (an ERA, a PDE-5i, or both).3
Watch this video
to learn more
What is Pulmonary Arterial Hypertension?
PAH is high blood pressure in the arteries of your lungs. It’s a serious condition that can make it difficult for blood to flow through your lungs.1,2
PAH can involve changes in the levels of three substances that occur naturally in your body.
 
 
Over time, these changes can cause the arteries in your lungs to become thick and stiff.
As this happens, the arteries of your lungs may tighten or narrow and scar, making it more difficult for blood to flow.
 
 
When blood flow is restricted, your heart must work harder to pump blood through the arteries of your lungs.
This can cause the muscles in your heart to thicken, which can make it more difficult for your heart to pump blood.
 
 
As time goes on, the strain on your heart can progressively worsen.
Understand your
options for
helping delay
disease
progression
UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.3
Talk to your doctor to see if there may be more you can do to help delay PAH progression.
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Take the quiz to test your knowledge of PAH
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Learn more about a comprehensive treatment plan that may include UPTRAVI
Discover if there are any additional angles you can explore with your doctor to help delay PAH progression.3
IMPORTANT SAFETY INFORMATION
EXPAND +
What is the most important information about UPTRAVI?
Who should not take UPTRAVI?
  • Do not take UPTRAVI if you take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

What should I tell my doctor before taking UPTRAVI?

Tell your doctor if you:

  • Have liver problems
  • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
  • Are pregnant or plan to become pregnant. It is not known if UPTRAVI will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI passes into your breast milk. You and your doctor should decide if you will take UPTRAVI or breastfeed. You should not do both
  • Have any other medical conditions
  • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements
What are the possible side effects of UPTRAVI?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Keep UPTRAVI and all other medicines away from children.

What other medicines might interact with UPTRAVI?
  • UPTRAVI and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor
How should I take UPTRAVI?
  • Take UPTRAVI exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI twice a day. Taking UPTRAVI with food may help you tolerate UPTRAVI better
  • Swallow UPTRAVI tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI
  • UPTRAVI is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

+
IMPORTANT SAFETY INFORMATION
What is the most important information about UPTRAVI?
+
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension

IMPORTANT SAFETY INFORMATION
What is the most important information about UPTRAVI?
Who should not take UPTRAVI?
  • Do not take UPTRAVI if you take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

What should I tell my doctor before taking UPTRAVI?

Tell your doctor if you:

  • Have liver problems
  • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
  • Are pregnant or plan to become pregnant. It is not known if UPTRAVI will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI passes into your breast milk. You and your doctor should decide if you will take UPTRAVI or breastfeed. You should not do both
  • Have any other medical conditions
  • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements
What are the possible side effects of UPTRAVI?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Keep UPTRAVI and all other medicines away from children.

What other medicines might interact with UPTRAVI?
  • UPTRAVI and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor
How should I take UPTRAVI?
  • Take UPTRAVI exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI twice a day. Taking UPTRAVI with food may help you tolerate UPTRAVI better
  • Swallow UPTRAVI tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI
  • UPTRAVI is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg
What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

References: 1. Humbert M, Lau EM, Montani D, Jaïs X, Sitbon O, Simonneau G, et al. Advances in therapeutic interventions for patients with pulmonary arterial hypertension. Circulation. 2014;130(24):2189-2208. 2. McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension. Circulation. 2009;119(16):2250-2294. 3. UPTRAVI® (selexipag) full Prescribing Information. Actelion Pharmaceuticals US, Inc.